Indinavir Goldenseal

Golden seal root inhibits various isoforms of cytochrome P450, including CYP3A4 (13). However, in a crossover study, goldenseal root (1140 mg bd for 14 days) had no effect on the pharmacokinetics of a single oral dose of indinavir 800 mg (14). 

Sandhu RS, PresciUa RP, SimoneUi TM, Edwards DJ. Influence of goldenseal root on the pharmacokinetics of indinavir. J Chn Pharmacol 2003 43(ll) 1283-8. 

Goldenseal root had no effect on the pharmacokinetics of a single dose of indinavir in one study. 

In a study in 10 healthy subjects, the peak plasma level and oral clearance of indinavir after a single 800-mg dose was not changed by goldenseal root (Nature s Way) 1.14 g twice daily for 2 weeks. In addition, there was no ehange in the indinavir half-life. Eight of the subjects had less than a 20% change in oral clearance, but one subject had a 46% increase and one a 46% decrease. ... 

No effects on digoxin were observed after oral administration of 3210 mg daily of goldenseal for 14 days (Gurley et al. 2007). No effects on indinavir were observed after administration of 2280 mg daily of goldenseal for 14 days (Sandhu et al. 2003). 

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