Indinavir Goldenseal root

Golden seal root inhibits various isoforms of cytochrome P450, including CYP3A4 (13). However, in a crossover study, goldenseal root (1140 mg bd for 14 days) had no effect on the pharmacokinetics of a single oral dose of indinavir 800 mg (14). [Pg.3026]

Sandhu RS, PresciUa RP, SimoneUi TM, Edwards DJ. Influence of goldenseal root on the pharmacokinetics of indinavir. J Chn Pharmacol 2003 43(ll) 1283-8. [Pg.3026]

Goldenseal root had no effect on the pharmacokinetics of a single dose of indinavir in one study. [Pg.830]

In a study in 10 healthy subjects, the peak plasma level and oral clearance of indinavir after a single 800-mg dose was not changed by goldenseal root (Nature s Way) 1.14 g twice daily for 2 weeks. In addition, there was no ehange in the indinavir half-life. Eight of the subjects had less than a 20% change in oral clearance, but one subject had a 46% increase and one a 46% decrease. ... [Pg.830]

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