Goldenseal root

Golden seal root inhibits various isoforms of cytochrome P450, including CYP3A4 (13). However, in a crossover study, goldenseal root (1140 mg bd for 14 days) had no effect on the pharmacokinetics of a single oral dose of indinavir 800 mg (14). 

Sandhu RS, PresciUa RP, SimoneUi TM, Edwards DJ. Influence of goldenseal root on the pharmacokinetics of indinavir. J Chn Pharmacol 2003 43(ll) 1283-8. 

Wound Powder 1 ounce (25 g) goldenseal root 1 ounce (25 g) usnea 1 ounce (25 g) echinacea root or seed 1 ounce (25 g) eucalyptus leaf 1 ounce (25 g) juniper leaf... 

Tincture Combination for Diarrhea 1 ounce (30 ml) goldenseal root tincture 1 ounce (30 ml) acacia tincture 1 ounce (30 ml) cryptolepsis tincture 1/3 ounce (10 ml) grapefruit seed extract Combine tinctures, shake well. 

Goldenseal root had no effect on the pharmacokinetics of a single dose of indinavir in one study. 

In a study in 10 healthy subjects, the peak plasma level and oral clearance of indinavir after a single 800-mg dose was not changed by goldenseal root (Nature s Way) 1.14 g twice daily for 2 weeks. In addition, there was no ehange in the indinavir half-life. Eight of the subjects had less than a 20% change in oral clearance, but one subject had a 46% increase and one a 46% decrease. ... 

A standardised goldenseal root extract did not alter the pharmacokinetics of digoxin. 

Upton, R. 2001. Goldenseal root Hydrastis canadensis Standards of analysis, quality control, and therapeutics, American Herbal Pharmacopoeia and therapeutic compendium. Santa Cruz, CA American Herbal Pharmacopoeia. 

Price, C.J. 2003. Final study report on the developmental toxicity evaluation for goldenseal root powder ( Hydrastis canadensis ) administered in the feed to Sprague-Dawley rats on gestational days 6 to 20. Govt. Rep. Announc. Index 18 130. 

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