Indexed MUX Parallel Mass Spectrometry

Sprayer interface (hence not compatible with ultrafast chromatography). The MUX technique was validated for rabbit, rat, mouse, and dog plasma, and the authors concluded that the technique is well-suited for simultaneous method validations and early discovery studies. 

Until very recently, metabolic stability screening and metabolite identification (metabolite ID) have been sequential processes that is, the metabolic stability assays are typically performed hrst to identify rapidly metabolized compounds and a follow-up metabolite ID study is performed next, typically at a 10-fold higher substrate concentration to ensure generation of sufficiently high-quality MS/MS information to support structure elucidation. 

Buspirone Imipramine Propranolol Verapamil SYR110155 SYR110180 SYR110182 SYR110184 

Fast turnover compounds automaticaliy reinjected for IDA acquisition 

Deterding, M. A. Moseley, K. B. Tomer, and J. W. Jorgenson, Nanoscale separations combined with tandem mass spectrometry, J. Chromatogr. 554 (1-2), (1991), 73-82. 

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