INDEX Prototypic classification

The approach to developing metrics for process safety is analogous to those that might be used to assess Occupational Exposure risk. One can cite as well several indices that have been developed as metrics for estimating and ranking the safety of a given process or chemical reaction, such as the DOW fire and explosion index,the Stoessel index ° for hazard assessment and classification of chemical reactions, the Inherent Safety Index, the Prototype Index for Inherent Safety, amongst others. ... 

Theophylline and polycyclic hydrocarbons in tobacco smoke (3-methylcholanthrene) represent a second type of enzyme inducer with broad induction effects. They induce CyP lA in which no change in P4go reductase occurs and a different terminal oxidase appears. After this type of induction, the clearance of tlieophylline but not that of antipyrine is increased. These substances have served as prototypes for the classification of enzyme inducers. Obviously, when patients are on a drug with a narrow therapeutic index, their dosing regimen would need to be adjusted should a known enzyme-inducing drug be added to or deleted from their therapy. 

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See also in sourсe #XX -- [ ]

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