INDEX hydrazines

Many of the salts which have been prepared are explosive and sensitive to heat or impact. These include chlorites of copper (violent on impact), hydrazine (monochlorite, inflames when dry), nickel (explodes at 100°C but not on impact), silver (at 105° or on impact), sodium, tetramethylammonium, mercury, thallium and lead (which shows detonator properties). Several other chlorites not isolated and unstable in solution include mono-, di- and tri-methylammonium chlorites. The metal salts are powerful oxidants [1], Chlorites are much less stable than the corresponding chlorates, and most will explode under shock or on heating to around 100°C [2], Individually indexed compounds are ... 

Many of the reactions of A-chloro- and A-bromo-imides are extremely violent or explosive. Those observed include A-chlorosuccinimide with aliphatic alcohols or benzylamine or hydrazine hydrate A-bromosuccimmidc with aniline, diallyl sulfide, or hydrazine hydrate or 3-nitro-A-bromophthalimide with tetrahydrofur-furyl alcohol l,3-dichloro-5,5-dimethyl-2,4-imidazolidindione with xylene (violent explosion). Individually indexed compounds are ... 

The remaining individually indexed eompounds are Almninium, 0048 Ammonimn phosphinate, 4554 Barimn phosphinate, 0210 t Benzaldehyde, 2731 1,4-Benzenediol, 2333 =N Bis(hydrazine)tin(ll) ehloride, 4070 Calcium acetylide, 0585 Calcium phosphinate, 3931 Chromium(Il) ehloride, 4052 Chromium(ll) oxide, 4241 Chromium(ll) sulfate, 4244 Copper(I) bromide, 0265 Diacetatotetraaquoeobalt, 1780 Diisobutylalmninimn hydride, 3082 t 1,2-Dimethylhydrazine, 0955... 

In a hood, to a well-stirred dispersion of 62 gm (1.35 moles) of methyl-hydrazine, 175 ml of chlorobenzene, and 20 gm of powdered, anhydrous sodium sulfate is added dropwise, with cooling, 61 gm (0.663 mole) of freshly distilled l-chloro-2-propanone. After the addition has been completed, the reaction mixture is stirred for 1 hr. The moist sodium sulfate is separated by filtration and the filtrate is distilled. The fraction boiling between 60°C and 64°C is collected as product, yield 16.8 gm (31 %) of a yellow liquid. On redistillation the boiling point is raised slightly to 61°-64°C, index 1.4300. 

Emil Fisoher (1852-1919), discovered phenyl-hydrazine as a PhD student In 1875, succeeded Hofmann at Berlin in 190Qwhdre he built the then largest chemical institute in the world, end was awarded the Nobel prize in 1902. As well as his work on indexes, he laid thd foundations of carbohydrate chemistry by completing the structure and synthesis of the main sugars, if only he hadn t also invented Fischer projections ... 

Several drugs, including salicylate (in overdose), alcohol, and possibly some hydrazines and other drugs which are metabolised by acetylation, have saturable elimination kinetics, but the only significant clinical example is phenytoin. With this drug, capacity-limited elimination is complicated further by its low therapeutic index. A 50% increase in the dose of phenytoin can result in a 600% increase in the steady-state blood concentration, and thus expose the patient to potential toxicity. Capacity-limited pathways of elimination lead to plasma concentrations of drugs which can be described by a form of the Michaelis-Menten equation. In such cases, the plasma concentration at steady state is given by... 

Most of the analyses were carried out using a High Performance Liquid Chromatograph (HPLC) equipped with a LiChrosorb RP-18 column (5pm, 250x4mm) and diode array (DA) and refractive index (RI) detectors. Two different methods were applied to analyse the compounds a derivatization method was used for the quantitative determination of aldehydes, aldols and unsaturated aldehydes, while a direct method was developed for measuring the contents of triols and organic acids. In the derivatization method [15], 2,4-dinitrophenyl-hydrazine (DNPH, Acros) was used as a reagent in acetonitrile (ACM) solution. 

As can be seen in table 2, a number of unit cells have been proposed for cellulose I-hydrazlne complexes over the years. Some of this diversity is almost certainly due to poor quality data, which can be Indexed in different ways. Nevertheless, visual comparison shows that our patterns are significantly different from those published previously, which probably reflects the fact that we used hydrazine containing no more than 3% water, as compared to up to 40% in earlier work. So far we have prepared three different cellulose Il-hydrazlne complexes, two for Fortisan (designated A and B) and one for Mercerized ramie. There may be some rationale for this complex A has only been obtained using anhydrous hydrazine, and the Fortisan and Mercerized ramie have different morphologies. However, it seems likely that all three complexes can be formed by both specimens once the preparation conditions are better understood. 

This structure presents more difficult problems than those treated above. Some 26 reflections are observed, but these are indexed by a four—chain unit cell, and this is insufficient data to allow for refinement of the number of parameters necessary to define such a structure. However, 22 of these reflections can be Indexed by a two-chain cell and we opted to work with this as an approximation to the full structure. Titration showed that the hydrazine content was close to one molecule per glucose residue. 

Within the last two decades, a number of chemical structures have been proposed as metal deactivators for polyolefins. These include carboxylic acid amides of aromatic mono- and di-carboxylic acids and N-substituted derivatives such as N,N -diphenyloxamide, cyclic amides such as barbituric acid, hydrazones and bishydrazones of aromatic aldehydes such as benzaldehyde and salicylaldehyde or of o-hydroxy-arylketones, hydrazides of aliphatic and aromatic mono- and di-carboxylic acids as well as N-acylated derivatives thereof, bisacylated hydrazine derivatives, polyhydrazides, and phosphorus acid ester of a thiobisphenol. An index of trade names and suppliers of a few commercial metal deactivators is given in Appendix A4. 

Other Names (2,4-Dmitrophenyl)hydrazine l-(2,4-Dinitrophenyl)hydrazine l-Hydrazino-2,4-dinitrobenzene DNPH NSC 5709 CA Index Name Hydrazine, (2,4-dinitrophenyl)-CAS Registry Number 119-26-6 Merck Index Number 3283 Chemical Structure... 

Other Names Benzoic acid, p-nitro-, hydrazide (p-Nitrobenzoyl)hydrazine 4-Nitrobenzen-ecarboxylic acid hydrazide 4-Nitrobenzhydrazide 4-Nitrobenzohydrazide 4-Nitrobenzoic acid hydrazide 4-Nitrobenzoic hydrazide 4-Nitrobenzoyl hydrazide 4-Nitrobenzoylhydrazine INHd 18 NSC 9804 p-Nitrobenzhydrazide p-Nitrobenzohydrazide p-Nitrobenzoic acid hydrazide p-Nitrobenzoic hydrazide p-Nitrobenzoyl hydrazide CA Index Name Benzoic acid, 4-nitro-, hydrazide CAS Registry Number 636-97-5 Merck Index Number Not hsted Chemical Structure... 

Inorganic hydrazine derivatives synthesis, properties, and applications / edited by K.C. Patil and Tanu Mimani Rattan, pa s cm Includes index. 

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