In vivo imaging technology

Multiplexed in vivo imaging is one of the important successful achievements of SERS-based assay technology in bio-related fields. Its medical application can serve as a simple and cheap diagnostic tool supporting traditional medical services such as diagnosis of cancers. 

Recent advances in imaging technology have allowed for the direct dynamic observation of biological processes, and provided unprecedented views into immune ceU migration in live animals that have deepened our understanding of the molecular control of immune ceU trafficking in vivo. This technology has recently been applied to study the molecular control of... 

CMUTs have the potential to make ultrasound a far more versatile and important imaging modality. This technology has made advances in acoustic matching and the microminiaturization of electronics. It enables higher-frequency imaging, allows clinicians to view small features in the body, and is useful for ultrasound imaging especially in the area of volumetric in vivo imaging, intravascular, and intracardiac research. 

Detection and spatial localization of the reporter are other important considerations for in vivo imaging. For example, reporter substrates that are radiopharmaceuticals formulated with either PET or SPECT radionuclides can be detected readily deep within the body, and well-developed technologies already exist to tomographic ally map the location of the signal source (the radio-tracer) within cross-sections of body tissue. The emitted radiation particles are for all practical purposes minimally attenuated by overlying tissues in mice and other small animals, and can be detected and directly mapped to specific deep body... 

Sokolov, K., Aaron, J., Hsu, B., Nida, D., Gillenwater, A., Follen, M., Macaulay, C., Adler-Storthz, K., Korgel, B., Discour, M., Pasqualini, R., Arap, W., Lam, W. and Richartz-Kortum, R. (2003) Optical systems for in vivo molecular imaging of cancer. Technology in Cancer Research ei Treatment, 2, 491-504. 

---