In vivo cardiovascular measurements

Many pathological events are associated with alterations of pH homeostasis, including tumors and cardiovascular diseases (121-124). The task to develop non-invasive methods for measuring pH in vivo has stimulated many researchers, especially in MR field, in designing probes sensitive to the hydrogen ion concentration (125-129). 

Effects of the test substance on the autonomic nervous system should be assessed. For example, binding to receptors relevant for the autonomic nervous system, functional responses to agonists or antagonists in vivo or in vitro, direct stimulation of autonomic nerves and measurement of cardiovascular responses, baroreflex testing, and heart rate variability can be used. 

Currently, 52 phenotype files are available, involving more than 3400 individuals and more than 800 types of measurements. These include both in vitro and in vivo studies, and cover all of the categories of evidence. A good representation of data on pharmacodynamics and pharmacokinetics of cancer therapies can be found, including studies on pediatric patients, as well as phenotypes associated with cardiovascular disease and hypertension. We also now accept micro array data in MAGE-ML format (16). 

FIGURE 4 J Miniaturized planar nine-site H /K selective sensor array applied to in-vivo measurements in porcine cardiovascular system. (From [107].)... 

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