In situ product removal ISPR

Woodley, J.M., Bisschops, M., Straathof, A.J.J. and Ottens, M. (2008) Future directions for in-situ product removal (ISPR). Journal of Chemical Technology and Biotechnology (Oxford, Oxfordshire 1986), 83 (2), 121-123. 

Also the use of mixed cultures, that is, two different species used together in fermentation can increase the resultant ethanol output. In addition to varying and optimizing the microorganism used, process management plays an important role in the ethanol yield. In this context it is possible via vacuum fermentation, in-situ-product-removal (ISPR), or integrated process management, to keep the... 

Altered process controls (e.g., vacuum fermentation, in-situ product removal (ISPR), integrated processes such as SSF, SSCF, CBP)... 

In Situ Product Removal (ISPR) in Whole CeU Biotechnology During the Last Twenty Years... 

When reactions are reversible or products unstable, it is attractive to int ate recovery and (bio-)reaction, that is in situ product removal (ISPR). Compatibility of bioconversion and separation conditions is a key issue in ISPR. It will be demonstrated in a later section that constraints in an integrated system are completely different from those in the individual, non-int ated process steps. It may also be attractive to combine separation steps. A well-known example is crystallization with a withdrawal of coarse crystals (integration of molecular and mechanical separations). Often, an optimal integrated system will operate imder conditions that are not equal to those of the individual and non-integrated conversion and separation steps. This is process integration at the level of unit operations. 

Stark, D., von Stockar, U. In Situ Product Removal (ISPR) in Whole Cell Biotechnology During the Last Twenty Years. Vol. 80, p. 149... 

A possible solution to overcome these thermodynamic limitations is the use of an in situ product removal (ISPR) technique [42]. This approach can be easily appHed when the co-substrate and the co-product have significantly different physical properties. For example, in the case of the IPA/acetone system used in several ADH-catalyzed ketone reductions, the co-product acetone is the most volatile compound in the reaction mixture. Therefore, it can be removed by a simple stripping process, such as by passing a continuous air stream (previously saturated with water and IPA) through the reaction mixture (Figure 2.1). 

Figure 2.1 Exploitation of the in situ product removal (ISPR) for controlling thermodynamic equilibria in substrate-coupled ADH-catalyzed reduction reactions.

Stark, D. and von Stockar, U. (2003) In-situ product removal (ISPR) in whole cell biotechnology during the last 20 years. Adv. Biochem. Eng. Biotechnol, 80, 149-175. 

Stams, A. J. M., Oude Elferink, S. J. W. H., Westermann, P. Metabolic Interactions Between Methanogenic Consortia and Anaerobic Respiring Bacteria. Vol. 81, p. 31 Stark, D., von Stockar, 17. In Situ Product Removal (ISPR) in Whole Cell Biotechnology During the Last Twenty Years. Vol. 80, p. 149... 

Application of In situ Product Removal (ISPR) Technologies for Implementation and Scale-Up of Biocatalytic Reductions... 

I 10 Application of in situ Product Removal (iSPR) Technologies for implementation... 

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