In situ crosslinking or polymerizing materials

The formation of covalent crosslinks between injectable precursor materials is a mechanism for creating solid gels after injection. These materials can crosslink or polymerize at the injection site due to various stimuli including temperature and light. Depending on the solubility of the precursors, the precursors may be injected as an aqueous solution or as an emulsion. Crosslinking generally 

Several eoneems have arisen for thermally activated systems in dmg delivery applieations. Burst release oeeurs in the time between injection and full curing of the Uquid preeursor materials (Hatefi and Amsden 2002). The use of free radical initiators may be undesirable for several reasons. Some of these reactions, such as in clinically used poly(methyl methaerylate) bone cement, can 

In situ erosslinking chemistries are desirable for biomedical applications because they do not require an initiator or external activation source. The most common of these are described in a review by Hoare and Kohane (a) reaction of 

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