In poststreptococcal glomerulonephritis

Ravnskov U. Exposure to organic solvents-a missing link in poststreptococcal glomerulonephritis Acta Med Scand 1978 203 ... 

The goals of therapy for streptococcal pharyngitis are to eradicate infection in order to prevent complications, shorten the disease course, and reduce infectivity and spread to close contacts. Sequelae that can be prevented by antibiotic use are peritonsillar or retropharyngeal abscess, cervical lymphadenitis, and rheumatic fever. There is no evidence that antibiotic use has an impact on the incidence of poststreptococcal glomerulonephritis. 

Serum complement levels are useful to distinguish between various forms of acute nephritis that may be due to either a primary renal disorder or a systemic disease. Glomerular diseases associated with decreased complement levels include systemic diseases such as systemic lupus erythematosus, subacute bacterial endocarditis, and cryoglobulinemia, and renal diseases such as acute poststreptococcal glomerulonephritis. Glomerular diseases in which serum complement levels are normal include systemic diseases such as Goodpasture s syndrome and renal diseases such as IgG-IgA nephropathy, antiglomerular basement membrane disease, and immune-complex disease. 

The marked inflammatory changes in the glomerular capillaries that accompany poststreptococcal glomerulonephritis significantly reduce the flow of blood to the filtering surfaces of these vessels. As a result, creatinine, urea, and other circulating metabolites that are filtered into the urine at a normal rate (the glomerular filtration rate or GFR) in the absence of kidney disease now fail to reach the filters, and, therefore, they accumulate in the plasma. 

Soylu, A., et al.. Posterior leukoencephalopathy syndrome in poststreptococcal acute glomerulonephritis. Pediatr Nephrol, 2001. 16(7) p. 601-3. 

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