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In platelet aggregation

Pharmacologic Therapy Treatments used to decrease bleeding time in patients with uremic bleeding include cryoprecipitate, which contains various components important in platelet aggregation and clotting, such as von Willebrand factor and fibrinogen. Cryoprecipitate decreases bleeding time within 1 hour in 50% of patients. However, cost and the risk of infection have limited the use of cryoprecipitate. [Pg.393]

Clezardin, R, Malaval, L., Morel, M. C., et al, Osteonectin is an alpha-granule component involved with thrombospondin in platelet aggregation. J. Bone Miner Res. 6, 1059-1070 (1991). [Pg.262]

Nitric oxide released from nitroglycerin stimulates guanylyl cyclase in platelets as in smooth muscle. The increase in cGMP that results is responsible for a decrease in platelet aggregation. Unfortunately, recent prospective trials have established no survival benefit when... [Pg.256]

Akiba et d. showed that EGb prevents the platelet aggregation induced by a combination of 100 fiM tert-butyl hydroperoxide and Fe2 . However, ginkgolides A, B and C, which are known to be PAF-antagonists, have no influence on this aggregation. Therefore, it was suggested that free radicals, but not PAF, might be involved in platelet aggregation induced by oxidative stress [140]. [Pg.180]

VII. Fibrinogen Binding to Integrins in Platelet Aggregation and Other Cellular Interactions... [Pg.277]

Farrell, D. H., Thiagarajan, P., Chung, D. W., and Davie, E. W. (1992). Role of fibrinogen alpha and gamma chain sites in platelet aggregation. Proc. Natl. Acad. Sci. USA 89, 10729-10732. [Pg.288]

Leung, L. L. (1984). Role of thrombospondin in platelet aggregation./. Clin. Invest. 74, 1764-1772. [Pg.291]

Q10 Yes, aspirin is used in the secondary prevention of a further stroke. Aspirin inhibits the cyclooxygenase (COX) enzyme responsible for producing thromboxane in platelets. Thromboxane is involved in platelet aggregation, an early step in blood coagulation. A low daily dose of aspirin (75 mg) inhibits thromboxane production, preventing platelet aggregation and blood clotting in arteries. [Pg.189]

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See also in sourсe #XX -- [ Pg.29 , Pg.672 ]



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Aspirin prevents platelet aggregation and may be helpful in the treatment of thromboembolic disease

COX enzymes in platelet aggregation

Flow Regimes and Corresponding Devices Used to Study in Vitro Platelet Aggregation

Ligands and Receptors Involved in Platelet Aggregation

Platelet Adhesion and Aggregation Responses in Hypertension

Platelet aggregation in whole blood

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