Importance and Measurement

Aqueous solubility is not usually considered a priori as a problem in the drug discovery of acidic compounds. More important issues are (i) the high serum albumin binding of stronger acids, (ii) the very low or nonexistent central nervous system penetration of stronger acids, (iii) the low volumes of distribution of acids limiting these mostly to plasma compartment targets, (iv) the possibility of formation of 

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Comparing two or more complex alternatives is more difficult than examining equipment capacity or first cost. Characteristics of alternatives should be weighted for relative importance and measured on a common scale to aEow proper evaluation. Many characteristics such as first cost, capacity, space requirement, and annual energy use can be measured objectively and used for system comparisons. Experience has shown that items such as maintenance expense, component life, and downtime can also be rehably estimated. Other factors, eg, system maintainabEity, flexibEity, and comfort, are more arbitrary. 

Notice diat we have five unknown coefficients (a, b, c, d and e) but four equations. This means we need an additional equation to solve a system of five equations widi five unknowns. An important and measurable parameter in a living system is the respiration quotient (RQ), which is defined as moles of C02 produced per mole of 02 uptake.1,2... 

Davies, J. E., The importance and measurement of surface charge species in cell behaviour at the biomaterial interface, in Surface Characterization of Biomaterials Progress in Biomedical Engineering, Volume 6 (B. D. Ratner, Ed.), pp. 219-234. Elsevier, New York, 1988. 

II. Types, importance and measurement of excited state distortions... 

TYPES, IMPORTANCE AND MEASUREMENT OF EXCITED STATE DISTORTIONS 123... 

Before the k,Jki,2 ratio can be considered as a valid criterion for assessing transition state structure, it needs testing for many more model reactions. The examples selected were not ideal as the low reactivity towards elimination made the significance of solvolytic side reactions more important and measure-... 

At the root of the classical thermodynamics of engines is the fact that work is an important and measurable quantity. However, work, while measurable, is rarely predictable. The work performed by a gas expanding in an engine piston can depend on pressure, volume, temperature, speed of the piston motion, frictional forces, and other factors in complex ways that are not fully understood. 

The constant k , in addition to Eq. (356), has another important and measurable physical interpretation. In particular, suppose that the condensation does not take place when 1 then the limiting value of Eq. (358) is the following ... 

The Tg or glass transition temperature is an important and measurable parameter giving information about the retrogradation behavior. Besides that, the Tg is also of great importance for the mechanical properties of the material. Beneath the glass transition temperature the material exists in an amorphous, frozen liquid structure with stiff and brittle behavior. Below its Tg the intermolecular bonds are not broken, due to the small amounts of room left for Brownian movement, as is stated in Eyring s free volume theory [6]. The specific volume increases relatively slowly with increasing temperature. When the material is heated up, at temperatures close to Tg the cohesive forces decrease drastically, the polymer expands, and the free volume increases to such an extent that there is... 

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