Implant local malignancy

Local sarcomas may develop in humans and domestic animals at sites of nickel implants and prostheses made of nickel. Latency of the implant sarcomas varies from 1 to 30 years in humans (mean, 10 years) and from 1 to 11 years in dogs (mean, 5 years). No cases of malignant tumors are reported at sites of dental nickel prostheses (Kasprzak 1987). 

Phase I-II trial results confirmed Ghadel as a safe treatment option for patients newly diagnosed with malignant gliomas who received post-operative radiation therapy. The study was free of perioperative mortality, and furnished no evidence of polymer-induced local or systemic toxicity. Of 22 patients, 21 received a pathological diagnosis of GBM median survival was 44 weeks from implantation with four patients surviving beyond 18 months. 

Williams JA, Yuan X, Dillehay LE, Shastri VR, Brem H, Williams JR. Synthetic, implantable polymers for local delivery of lUdR to experimental human malignant glioma. Int J Radiat Oncol Biol Phys 1998 42 631-639. 

Observational studies Another radioactive iodine compound, I, can be used in seed implants as an adjunct to surgical resection of advanced thoracic malignancies. In 59 patients who had close or positive margins on the surgical resection specimen, the use of I seeds resulted in local control rates of 80% at 1 year and 67% at 2 years [10 ]. Grade 3 and 4 adverse reactions, which were reported in seven subjects, included esopha-geal/bronchialfistulae, radiation pneumonitis, hydropneumothorax, persistent pneumothorax, and possible aortic rupture [11 . ... 

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