Impedimetric Immunosensors Using Interdigitated Array Microelectrodes

1 Impedimetric Immunosensors Using Interdigitated Array Microelectrodes 

Therefore, the size of the IDpE electrode must be chosen for different biological entities in consideration of their sizes (could be nanometer to micrometer) to achieve a sensitive biosensor for that type of biological entity. For example, micrometer IDpE electrodes are suitable for sensing of biological cells, while nanometer IDpEs are more proper for sensing DNA, up to 200 nm for a probe-DNA binding, and in the order of lO-lOOnm for an 

The same authors developed a much more robust label-free impedimetric immunosensor, based on the same IDpE arrays conveniently derivatized through covalent procedures to ensure reliability and to prevent nonspecific adsorption [42]. Atrazine-BSA was covalently immobilized on the surface of the IDpEs previously activated with (3-glycidoxypropyl)trimethoxysilane via the side chain amino groups of lysines or arginines with the epoxy groups on the device surface. Before, the gold electrodes were blocked 

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