Impact of Solid-State Form on API and Product Properties

2 Impact of Solid-State Form on API and Product Properties 

Another key property of the drug product, which can be impacted by the solid form, is chemical stability [22], Drug degradation in solid dosage forms is mostly 

Chemical Physical Mechanical Surface Thermodynamic Kinetic 

Chemical stability/ Stability Compactability Surface free energy Solubility Dissolution rate 

A change in the solid form may lead to a different crystal morphology, which may have an impact on processibility of the drug product due to the different mechanical and flow properties [25], For example, needle-shaped crystals are generally undesirable for pharmaceutical applications since they are difficult to process [26]. 

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