Immunophenotyping defined

Although it has been proven disadvantageous to shorten maintenance treatment, whether or not extended maintenance of up to 3 years is offering any beneficial effect in the context of different treatment strategies remains to be evaluated, particularly in males patients. Other issues that must be resolved in the future include differences in requirements for maintenance therapy in specific childhood ALL patient subsets (e.g., those defined immunophenotypically or genetically). These questions are still under investigation. 

Lymphoid neoplasms in both the REAL and the WHO classifications are defined as specific entities based on morphology, immunophenotype, genotype, and clinical characteristics (HI 1, J2). These neoplastic entities, however, tend to mimic their... 

Z3. Zukerberg, L. R., Medeiros, L. J., Ferry, J. A., and Harris, N. L., Diffuse low-grade B-cell lymphomas. Four clinically distinct subtypes defined by a combination of morphologic and immunophenotypic features. Am. J. Clin. Pathol. 100, 373-385 (1993). 

The immunophenotype of undifferentiated and dedifferentiated endometrial carcinomas, as defined by Silva and colleagues, has been explored in recent publications. It should be noted, however, that... 

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