Immunological Receptors

D-penicillamine a well-recognized complication of the use of D-penicillamine is a myasthenic syndrome. Most reported cases of myasthenic syndrome are women and the ocular muscles appear to be particularly commonly affected at early stages of the abnormality. The onset of the myasthenic syndrome can range between a few months and many years, and is not always reversible. There is a clear immunological basis to this problem, because it is associated with raised anti-acetylcholine receptor antibodies circulating in the serum. Antibody levels fall when the drug is withdrawn, and this, in turn, is associated with clinical improvement. How the... 

Walker CM, Levy JA (1989) A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66 628-630 Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, Stevens R, Hazen A, Blaese RM, Chen CC, Lehman SF, Palensky J, Wittes J, Davey RT, Falloon J, Polls MA, Ko-vacs JA, Broad DF, Levine BL, Roberts MR, Masur H, Lane HC (2000) Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96 467 74... 

Key Words Chemokines receptors GPCR structure inflammation immunology biochemistry. 

The redundancy and cross talk between chemokines and receptors in vivo creates a complex immunologic and regulatory communication system. As proposed by Rot and von Andrian (14), our challenge is therefore to understand... 

Several problems limit the interpretation of sTNF-R and IL-lra levels, including the specificity of currently available assays for free receptor or receptor-ligand complexes (El3). In addition, acute or chronic organ dysfunction may significantly alter the clearance of both sTNF-R and IL-lra, and the potential impact of established immunological dysfunction upon their production has not been clarified. 

G10. Girardin, E., Roux-Lombard, P Grau, G. E., Suter, P., and Gallati, H., and Dayer J. M. The J5 Study Group. Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. Immunology 76,20-23 (1992). 

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