Immune system dysregulation

RA results from a dysregulation of the humoral and cell-mediated components of the immune system. Most patients produce antibodies called rheumatoid factors these seropositive patients tend to have a more aggressive course than patients who are seronegative. 

If one considers the immune system as a continuum, dysregulation of immune function can also be expressed in the development of immune mediated diseases via enhanced... 

The pathogenesis of alcoholic liver disease is a multifactorial process involving metabolic repercussions of ethanol oxidation in the liver, dysregulation of fatty acid oxidation and synthesis, and activation of the innate immune system by a combination of direct effects of ethanol and its metabolites and by bacterial endotoxins that access the liver as a result of ethanol-induced changes in the intestinal tract. Tumor necrosis factor- , a proinflammatory cytokine that is consistently... 

These evidences suggests that dysregulation in immune system may be associated with pathogenesis of HTLV-I associated neurologic diseases and may be responsible for local parenchymal ( by-stander ) damage. 

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