Oral contraceptives imipramine

Abernethy DR, Greenblatt DJ, Ochs HR, et al Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives. Clin Pharmacol Ther 33 628-632, 1983 Abernethy DR, Greenblatt DJ, Shader Rl Imipramine disposition in users of oral contraceptive steroids. Clin Pharmacol Ther 35 792-797, 1984 Abou-Saleh MT Lithium and bipolar illness, in Long-Term Treatment of Depression. Edited by Montgomery SA, Rouillon F. Chichester, England, Wiley, 1992, pp 113-138... 

Oral contraceptives reduce the clearance of imipramine, probably by reducing hepatic oxidation, and thus increase its half-life. Hydroxylation of amitriptyline is inhibited by contraceptive steroids. The clinical significance is uncertain, but there is at least anecdotal evidence of an increase in antidepressant adverse effects (360). Caution should be exercised when tricyclic antidepressants are used long term in women taking oral contraceptives. 

Abernethy DR, Greenblatt DJ, Shader RI. Imipramine disposition in users of oral contraceptive steroids. Clin Pharmacol Ther 1984 35(6) 792-7. 

Paroxetine and cimetidine cause small, clinically irrelevant, increases in darifenacin levels. Darifenacin increases imipramine levels, and caution is required with this and other tricyclics. Darifenacin does not significantly affect the pharmacokinetics of midazolam or combined oral contraceptives. 

Drugs that may be affected by fosamprenavir include the following Amiodarone, amitriptyline, benzodiazepines, calcium channel blockers, cisapride, contraceptives (oral), cyclosporine, ergot derivatives, HMG-CoA reductase inhibitors, imipramine, itraconazole, ketoconazole, lidocaine (systemic), methadone, pimozide, quinidine, rifabutin, sildenafil, tacrolimus, vardenafil, warfarin. 

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