Imipenem-cilastatin sodium

Ryan [36] developed a method to determine the relative degree of crystallinity (RDC) of imipenem in lypophilized combination products containing imipenem and amorphous cilastatin sodium. He used the relationship... [Pg.198]

Pharmacology This product is a formulation of imipenem, a thienamycin antibiotic, and cilastatin sodium, the inhibitor of the renal dipeptidase, dehydropeptidase-1, which is responsible for the extensive metabolism of imipenem when it is administered alone. Cilastatin prevents the metabolism of imipenem, increasing urinary recovery and decreasing possible renal toxicity. The bactericidal activity of imipenem results from the inhibition of cell-wall synthesis, related to binding to penicillin-binding proteins (PBP). [Pg.1535]

Although not a polymorphic phase in the formal sense, the amorphous state can represent an important quantity of measure in a crystalline sample. A general XRPD procedure for such work has been described,31 and similar approaches have been reported for cilastatin sodium,32 caffeine,33 imipenem,34 acetaminophen,35 and a Lumaxis analog.36... [Pg.44]

Verpooten GA, Verbist L, Buntinx AP, Entwistle LA, Jones KEI, De Broe ME. The pharmacokinetics of imipenem (thienamycin-formamidin) and the renal dehydropeptidase inhibitor cilastatin sodium in normal subjects and patients with renal failure. Brit J Clin Pharmacol 1984 18 193-193. [Pg.46]

Sodium salt, CggH N NaOgS, cilastatin sodium. Off-white to yellowish-white hygroscopic, amorphous solid. pKa, 2.0 pKa2 4.4 pKa, 9.2. Very sol in water, methanol. Combination with imipenem Primaxin, Zienam. [Pg.353]

Zaccardelli, D.S. Krcmarik, C.S. Wolk, R. Khalidi, N. Stability of imipenem and cilastatin sodium in total parenteral nutrient solution. J.Parenter.Enteral.Nutr, 1990, 14, 306—309... [Pg.333]

Prim dn IV Injection (Imipenem monohydrate/Cilastatin sodium). Merck Sharp Dohme Ltd. UK Summary of product characteristics, October 2005. [Pg.1016]

Forsyth R. Ip D. Determination of imipenem and cilastatin sodium in Primaxin by first... [Pg.128]

Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1 1 ratio in combination with cilastatin—the sodium salt of [/ -[/ ,5 -(Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid... [Pg.464]

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