Iminostilbene derivatives

Carbamazepine is a tricyclic iminostilbene derivative and structurally related to the tricyclic antidepressants. It is used as a first-line agent for the management of generalized tonic-clonic epilepsy. It is also highly effective for partial seizures but has no efficacy in patients with absence seizures or atonic seizures. In epilepsy it supposedly has the same mechanism of action as phenytoin. An other well... 

Carbamazepine is an iminostilbene derivative used as an anticonvulsant and for the relief of pain associated... 

Chemical/Pharmaceutical/Other Class Synthetic iminostilbene derivative structurally similar to imipramine, a tricyclic antidepressant. While unrelated structurally, carbamazepine shares a similar therapeutic action with phenytoin Chemical Formula C15H12N2O Chemical Structure ... 

A -Acyl derivatives of azepine like the iminostilbene 197 (Scheme 52) react in different ways depending on the nature of the N substituent if it is acyl, aroyl, or ethoxycarbonyl, the preferred reaction is dimerization on the other hand, N-tosyl compounds give PFR [154]. 

Labeling of carbamazepine, an anti-epileptic, is carried out by conjugating the alkyne dicobalt hexacarbonyl entity to an amino derivative of the analyte 31 via peptide coupling with (N-succinimidyl-4-pentynoate) hexacarbonyl dicobalt 32 (Scheme 8.15) [45]. The amino derivative of carbamazepine 31 is prepared in one step from iminostilbene. (N-succinimidyl-4-pentynoate) hexacarbonyl dicobalt 32 is synthesized in two steps by esterification of pentynoic acid in the presence of NHS and DCC, followed by complexation of the triple bond by Co2(CO)g to give the tracer 33 [46]. 

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