Iminodiacetate complexes

Crans, D.C., F. Jiang, I. Boukhobza, I. Bodi, and T. Kiss. 1999. Solution characterization of vanadium(V) and -(IV) V-(phosphonomethyl)iminodiacetate complexes Direct observation of one enantiomer converting to the other in an equilibrium mixture. Inorg. Chem. 38 3275-3282. 

Technetium(III) complexes with aminocarboxylato ligands have been reported but none are well characterized (241). " Tc-iminodiacetate complexes formed with 2,6-alkylphenyl [ArNHCOCH2N(CH2COO)2] " ligands are used to image the hepatobiliary system. Studies with Tc show evidence for [Tc L2]" in the radiopharmaceutical preparations. 

Scheme 23 Template polymerization of Cu(II)-iminodiacetate complexes. Strategically distributed copper binding sites are formed through coordination to bis-imidazoles in prepolymerization mixtures followed by template removal.

The same applies to Th, as is evident from a comparison between the values of AG for the oxy- and iminodiacetate complexes formed by Th and (Table 21.17). For H", the N complex is much more stable forTh, only slightly so. 

Phosphoproteins (various). Purified by adsorbing onto an iminodiacetic acid substituted agarose column to which was bound ferric ions. This chelate complex acted as a selective immobilised metal affinity adsorbent for phosphoproteins. [Muszyfiska et al. Biochemistry 25 6850 1986.]... 

Two-dimensional protein layer orientation could be also effected by metal-ion coordination Monolayer of iminodiacetate-Cu(II) lipid was successfully employed as substrate for oriented immobilization of proteins naturally displaying histidine residues on their surface [37]. Affmity-resin-displaying Ni(II) complexes could also be successfully employed for oriented protein immobilization [38]. 

Complexes of IrIV with iminodiacetic acid (HN(CH2COOH)2), nitrilotriacetic acid (N(CH2COOH)3), and trara,s-l,2-cyclohexanediaminetetraacetic acid (L) have been studied by spectroscopic methods.43... 

Products of substitution of inosine and guanosine 5 -monophosphate for chloride or for water on ternary aminocarboxylate complexes such as [Pd(mida)(D20)], where mida = IV-methyliminodiacetate, or [Pd2(hdta)Cl2]2-, where hdta = 1,6-hexanediamine-A(7V,./V,./V,-tetraace-tate, is subject to mechanistic controls in terms of number of coordinated donor atoms and pendant groups and of the length of the chain joining the functional groups in the bis-iminodiacetate ligands. These factors determine the nature and stereochemistry of intermediates and the relative amounts of mono- and bi-nuclear products (253). 

The complexity that may arise even for a relatively simple molecule is illustrated by iminodiacetic acid, H02CCH2NHCH2C02H. This acid has three crystal forms. The bond angles and lengths are essentially the same in all the forms, but the torsional angles differ, providing three different molecular conformations (19). In addition, one of the forms has two symmetry-independent molecules, of slightly different conformations, in its asymmetric unit. 

During the early sixties Thompson and Loraas (77) reported the formation of mixed complexes of reasonable stability (log K 3.0—5.3) between lanthanide—HEDTA and ligands such as EDDA (N,N -ethylenediaminediacetic acid), HIMDA (N-hydroxyethyliminodiacetic acid) and IMDA (iminodiacetic acid). This observation together with the remarkably large formation constants (72) for the bis-EDDA complexes [log A2 =4.73 (La) 8.48 (Lu)] suggested a coordination number larger than six for the tripositive lanthanide ions in aqueous solution, in view of the fact that mixed chelates of the t5q>e M (HEDTA) (IMDA) axe not formed when M =Co(II), Ni(II) or Cd(II). 

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