Hydrazones imines

Carbon—nitrogen double bonds in imines, hydrazones, oximes, nitrones, azines, and substituted diazomethanes can be cleaved, yielding mainly ketones, aldehydes and/or carboxyHc acids. Ozonation of acetylene gives primarily glyoxal. With substituted compounds, carboxyHc acids and dicarbonyl compounds are obtained for instance, stearoHc acid yields mainly azelaic acid, and a smaH amount of 9,10-diketostearic acid. 

Replacement of carbonyl oxygen by nitrogen (imines, hydrazones, osazones etc.)... 

Reduction of imines, hydrazones, or other compounds containing the... 

The alkylation of metalated imines, hydrazones, 4,5-dihydrooxazoles, 4,5-dihydroisoxazoles, 5,6-dihydro-4/7-1,2-oxazines and 2,5-dialkoxy-3,6-dihydropyrazines (i.e., azaenolates) is a commonly used method in asymmetric synthesis of enantiomerically enriched aldehydes, ketones, spiroacetals, amines, /J-oxo esters, carboxylic acids, lactones, 1,3-amino alcohols, /(-hydroxy ketones and amino acids. 

Thermodynamic template reactions allow the formation of hydrazones from hydrazines and carbonyl compounds, in the same manner as simple imines are formed. However, in many cases it is more convenient to form hydrazones in non-template reactions, as they are generally easier carbonyl derivatives to isolate than are simple imines. Hydrazone complexes often are capable of further manipulation and both aspects of synthesis and reactivity will be combined in this section. 

This compound forms coloured crystalline imines (hydrazones) with most carbonyl compounds—before the days of spectroscopy these were used to characterize aldehydes and ketones (see p. 351). 

Fur an 5-[2-(Dimethylamino-methy-len)-hydrazonomethyl]-2-nitro-E14b, 670 (Imin - Hydrazon)... 

Hydrogen cyanide adds to the carbon-nitrogen double bonds present in various aldehyde and ketone derivatives, like those in imines, hydrazones, oximes, and Schiff bases. In each instance, a new carbon-carbon linkage is formed. Thus, the reaction of dry hydrogen cyanide with an imine... 

Hydrogen reduction of organic nitrogen compounds occurs readily in the presence of homogeneous and heterogeneous catalysts, " , e.g., nitro, nitroso, oxime, nitrile, imine, hydrazone and azide compounds are reduced ... 

TABLE Xn. IMINES, HYDRAZONES, SEMICARBAZONES, AND OXIMES Continued)... 

Nitrile imines Hydrazones undergo a thermal 1,2-hydrogen shift to afford azome-thine imine intermediates which in turn can undergo 1,3-dipolar cycloaddition [51] bipyrazoles were obtained from pyrazolylhydrazones under the action of microwave irradiation. The synthesis involved [3+2] cydoaddition with alkenes after... 

Functional groups that are stable to reduction during azide hydrogenolysis include benzyl ester, alkyl chloride, benzyl ether, epoxide, alkoxy imine, hydrazone, nitrile, aldehyde, and ketone (Scheme 33)P9H43]... 

A short review examines nucleophilic trifluoromethylation of C=N bonds imines, hydrazones, and nitrones, together with iminium cations and azomethine imines, mainly focusing on the Ruppert-Prakash reagent, TMS-CF3. ... 

Electrophilic Imine, Hydrazone, Oxime Ester as the Hydride Acceptors... 

H-Chemical Shifts in Oximes, Imines, Hydrazones and Azines (6 in ppm relative to TMS)... 

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