Imidazoline structures

Chemical Name 4,5-dihydro-2-(1-naphthalenylmethyl)-1 H-imidazole Common Name 2-(1-naphthylmethyl)imidazoline Structural Formula ... 

Therapeutic Function Peripheral vasodilator Chemical Name 4,5-dihydro-2-(phenylmethyl)-1H-imidazole Common Name Benzazoline 2-benzyl-4,5-imidazoline Structural Formula r... 

The imidazoline receptor is a hypothetical receptor for a subgroup of a2 adrenergic agonists, which are characterized by their imidazoline structure (e.g. moxoni-dine). So far, there is no proof of the existence of imidazoline receptors. 

For personal care applications, the major products in this group are amphoacetates or amphodiacetates , generally based on alkyl hydroxyethyl imidazolines from either a whole coconut fatty acid distribution or a lauric cut. The ampho portion of their name is a convention established by the International Nomenclature Committee for Cosmetic Products (INCI) to indicate that they are derived from imidazoline structures. The INCI nomenclature applied to these materials, amphoacetate and amphodiacetate, is intended to give an indication of the stoichiometry used to produce them, either 1 or 2 mol of sodium chloroacetate is added to each mole of fatty imidazoline. Modern analytical methods have been used to determine the structure of these products and almost all of them are actually monoacetates . The main difference between amphoacetates and ampho diacetates is the composition of the by-products. 

Some products in the amidoamine group are manufactured to contain a significant amount of imidazoline structures. This is accomplished by a high reaction temperature that converts the open amide structure to the cyclic imidazolin with loss of water. This conversion leads to lower viscosities since the concentration of the polar amide group is reduced. 

A reactivity index suitable for use in Equation 1 was calculated by using the simple molecular orbital techniques described by the Pullmans (14). Many indexes may be deduced from this type of procedure. The one that seemed to have the most significance for the correlation was the energy of the highest occupied molecular orbital (HOMO). This index is a relative measure of the ability of an electron to be transferred to an acceptor molecule. The calculations were performed on the substituted phenol in the imidazoline structure. This simplification was made since it could be assumed that any perturbation caused by the imidazole would be insulated from the rest of the molecule by the methylene group. 

A study by Timmermans and van Zwieten (8) on QSAR in Centrally Acting Imidazolines Structurally Related to Clonidine led to the development of equation (U). There were 27 observations and effectively... 

The most important products of this group are the coco derivatives cocoamphoglycinate, cocoam-phocarboxyglycinate, cocoamphopropionate, and cocoamphocarboxypropionate. In former times, these were referred to as imidazoline derivatives, but chemical studies have shown that the imidazoline structure hydrolyzes completely during the production process. 

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