Imidazoline pancreatic

Some authors faced with experimental data from functional studies that did not fulfilled the criteria of definition of Ii- or l2-receptors this was particularly the case in investigations concerning the possible role of pancreatic imidazoline receptors but it was also evoked with regard to sympathetic presynaptic imidazohne receptors. Such sites were provisionally named non-Il, non-l2 receptors [24,25]. 

Some imidazoline substances were shown to enhance the glucose induced insulin release from pancreatic p cells [35,58]. This effect was not mediated by a-adrenoceptors but appeared to involve some specific imidazoline sites [86]. Moreover, these cells expressed recognition sites specific for imidazolines but different from the II- or l2-receptors. In fact, imidazoline compounds such as efaroxan and antazoline were shown to potently stimvdate insulin secretion ( fig 2). The latter effect was also attributed to a specific action on pancreatic imidazohne receptors [59]. 

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