Methyl-2-imidazoline-4-carboxylic acid

C10H10CI2N20 2-((3,4-dichlorophenoxy)methyl)-2-imidazolin 23712-05-2 25.00 1.3324 2 19162 C10H1002 indan-2-carboxylic acid 25177-85-9 27.69 1.0799 2... 

Carbimazole. 2,3-Dihydro-3-mrthyi-2-thioxo-lH-imidazole-l-carboxylic acid ethyl ester, l-ethoxycarbonyl-3-methyl -2-thio-4-imidazoline ethyl 3 -methyl -2 -thioimid azoline-1 -carboxylate 1 -methyl -3-carbethoxy-2-thiogly-oxalone athyromazole Neo-mercazole Neo-Thyreostat. C,H10N2OjS mol wt 186.23. C 45.15%, H 5.417=, N 15,047=., O 17.187=, S 17.22%. Prepn RimingtOn et al,... 

Disodium lauroamphodipropionate Disodium oleamido MIPA-sulfosuccinate Disodium oleth-3 sulfosuccinate N,N-Distearyl-N-methyl-N-(3-sulfopropyl)-ammonium betaine Isostearamidopropyl betaine Isostearamidopropyl ethyidimonium ethosulfate Lauramidopropyl betaine Laureth-6 carboxylic acid Lauryl hydroxyethyl imidazoline MEA-lauryl sulfate Oleamidopropyl betaine PEG-6 cocamide PEG-3 cocamine oxide PEG-15 cocopolyamine PEG-78 glyceryl cocoate PEG-200 glyceryl tallowate PEG-75 mango glycerides PEG-75 shea butter glycerides PEG-80 sorbitan laurate PEG-40 sorbitan perisostearate... 

Our motivation for investigating thioamide derivatives, which potentially can form N-H... S interactions, arises from the presence of the -N(H)-C(=S)- residue, and derivatives thereof, in several dmgs [20], see Scheme 6.2 for chemical structures of these species. Thus, the antithyroid drugs 6-n-propyl-thiouracil (I) and l-methyl-3//-imidazole-2-thione (II, Methimazole , also marketed as Tapazole ) feature the -N(H)-C(=S)- functional group [21]. Hyperthyroidism may be treated with 3-methyl-2-thioxo-4-imidazoline-l-carboxylate (III, Carbimazole ) which is metabolised in vivo to the active form, known as Methimazole [22]. Anti-tubercular agents containing the thioamide residue and which inhibit mycolic acid synthesis include 2-ethyl-thioisonicotinamide (IV, Ethionamide ) and its -propyl derivative (Prothionamide ) [23-25]. 

Other similar methods which involve cyclization of iV-substituted diaminoalkenes or -alkanes include the preparation of 2-alkyl- and 2-acyl-l-methylimidazole-4-carboxylates from methyl (Z)-j -dimethylamino-a-isocyanoacrylate (191) in reaction with an alkyl or acyl halide <82LA2093>, the preparation of perfluorinated 3-imidazolines (192) <83S169>, the high yield synthesis of 2-imidazolines by decay of phosphaza compounds (193) in a version of the intramolecular Staudinger reaction <85T793>, and the formation of 1,3-diaroylimidazolidines (34-71%) when bis-alkylidene-or -arylidene-ethylenediamines react with acid chlorides in polar solvents (Scheme 129)... 

---