Imidazoles Imides

M. Ghaemy, M. Hassanzadeh, M. Taghavi, S.M.A. Nasab, Synthesis and characterizahon of trifluoromethylated poly(ether-imidazole-imide)s based on unsymmetrical diamine bearing carbazole and unidazole ctiromophores in ionic hquids study of electrochemical properties by using nanocomposite electrode, J. Ruorine Chem. 142 (2012) 29 0. 

Another interesting feature of the reactivity of imidazol/imid-azolin-2-ylidenes in these MCRs is the influence of the N-snbstitnents. The same authors observed that employing (V-alkyl imidazol-2-ylidenes, the reaction took an entirely... 

Much work has been done on this interesting group of condensation polyimides [219]. Trying to combine the good thermal stability of other heterorings and the availability of polyimide monomers, a considerable number of mixed polyheterocycles has been synthesized. Among other heterocyelic copolyimides, poly(imidazole imide)s [220,221], poly(oxadiazole imide)s [222,223], poly(benzazole imide)s [224,225], poly(quinoxaline-imide)s [226], and poly(quinazolinedione imide)s [227] have been synthesized. 

Later we reported [84] the (V-aiylation of imidazoles, imides, amines, amides, and sulfonamides with arylboronic acids using a recyclable Cu(0Ac)2 H20/[bmim] [BF4] system in the absence of a base or additive to afford the corresponding (V-arylated products in good to excellent yields. 

The use of [Cu(MeCN)4] as a starting material simplifies the preparation of copper(I) complexes of substituted imidazoles (imid = 1-, 2-, or... 

The same system of nomenclature can be used to differentiate tautomers of types 22 and 23, which would be named 4-methyl-IH-imid-azole and 4-methyl-3//-imidazole, respectively. 

PREPARATION OF 2,4-DISUBSTITUTED IMIDAZOLES 4-(4-METHOXYPHENYL)-2-PHENYL-lH-IMID AZOLE... 

Aldoximes are readily dehydrated with N, N -carbonyldiimidazole (CDI). An intermediate azolide is formed in the process under elimination of one mole of imidazole, which fragments into a nitrile through elimination of CO2 and a second mole of imid-azole.[1],[2]... 

The activation of a carboxylate group with CDI proceeds to give an intermediate imide with imidazole as the active leaving group. In the presence of a primary amine-containing compound, the nucleophile attacks the electron-deficient carbonyl, displacing the imidazole and forming a... 

The imidazole complex raras-[Ir(imid)2Cl4]- is stable for days in neutral aqueous solution, and for hours in the presence of added thiocyanate. Addition of silver nitrate precipitates the silver salt of the complex, with no indication of Ag+-catalyzed removal of coordinated chloride. Thus this iridium(III) complex is substitutionally much more inert than its much-studied (because (potentially) anti-tumor) ruthenium(III) analogue (96). 

Similar Neber rearrangements were used to produce 528, an intermediate for an efficient synthesis of 2-imidazol-2-yl acetates 530 (equation 234). Condensation of the a-amino ketals 528 with imidates 529, followed by cyclization in refluxing acidic dioxane, yielded 2-imidazol-2-yl acetates 530 in a one-pot reaction. 

The synthesis of eprosartan mesylate (6) by SmithKline Beecham Pharmaceuticals is described in Scheme 9.9. The synthesis of the precursors 43 and 45 were required for imidazole formation. Thus, valeronitrile (40) was converted to the imidate salt 41 with... 

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