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Eprosartan mesylate

USAN Eprosartan mesylate Trade name Teveten SmithKIine Beecham Launched 1997 M.W. 423.5 (parent)... [Pg.130]

Eprosartan mesylate (6) was the first non-biphenyltetrazole angiotensin 11 ATi receptor antagonist. The absolute bioavailability of 6 is 15%, and peak plasma concentration is reached 1 - 2 h after oral administration. Administration of food with 6 delayed absorption by 25%. The elimination half-life varied from 5 to 7 h. Eprosartan mesylate (6) is ehmi-nated by the bile and kidneys in a 90 10 ratio as unchanged drug. [See McClellan and Balfour (1998).]... [Pg.138]

The synthesis of eprosartan mesylate (6) by SmithKline Beecham Pharmaceuticals is described in Scheme 9.9. The synthesis of the precursors 43 and 45 were required for imidazole formation. Thus, valeronitrile (40) was converted to the imidate salt 41 with... [Pg.138]

Scheme 9.9. The SmithKline Beecham synthesis of eprosartan mesylate (6). Scheme 9.9. The SmithKline Beecham synthesis of eprosartan mesylate (6).
Angiotensin II receptor antagonists candesartan cilexetil eprosartan mesylate irbsartan... [Pg.603]

Teveten (Eprosartan mesylate). Kos Pharmaceuticals, Inc. US Prescribing information, September 2005. [Pg.38]

See other pages where Eprosartan mesylate is mentioned: [Pg.401]    [Pg.586]    [Pg.131]    [Pg.131]    [Pg.132]    [Pg.138]    [Pg.138]    [Pg.138]    [Pg.139]    [Pg.442]    [Pg.113]    [Pg.113]    [Pg.233]    [Pg.233]    [Pg.2]   
See also in sourсe #XX -- [ Pg.130 , Pg.138 ]

See also in sourсe #XX -- [ Pg.442 ]

See also in sourсe #XX -- [ Pg.233 ]



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