Imaging mass spectrometry studies

In a separate study, a protocol for Matrix-assisted laser desorption-ionization (MALDI) imaging mass spectrometry (IMS) has been proposed.18 This IMS technique provides a new approach to visualize spatial distribution of thousands of molecular species, including peptides, proteins, and their metabolites in two- or three-dimensional levels. This approach may also provide a straightforward method of determining the tissue distribution of multiple peptides or proteins in a quantitative manner.18 Chu et al.19 reported a nondestructive molecular extraction method to obtain proteins from a single FFPE or frozen tissue section, without destroying the tissue morphology, such... 

In the literature these studies are classified as imaging mass spectrometry (IMS) and defined as the investigation of the chemical profile of a sample surface with a submicron lateral resolution and chemical specificity. The main aim is to use the power of mass spectrometry techniques to create chemical images showing the distribution of compounds ranging in size from atomic ions and small molecules to large proteins. 

Imaging mass spectrometry by LA-ICP-MS can be employed for studies of homogeneous element distribution in material science (e.g., in semiconductors or ceramics) for future application in the microelectronics industry. 

Zheng L, McQuaw C, Ewing A, Winograd N (2007) Sphingomyelin/phosphatidylcholine and cholesterol interactions studied by imaging mass spectrometry. J Am Chem Soc 129(51) 15730-15731. doi 10.1021/ja0741675... 

Snginra, Y., Shimma, S., Konishi, Y., Yamada, M.K., Seton, M. (2008) Imaging mass spectrometry technology and application on ganghoside study visualization of age-dependent accumulation of C20-ganglioside molecnlar species in the mouse hippocampus. PLoS ONE, 3, e3232. 

Gormanns et al employed SVMs to study images obtained by multiisotope imaging mass spectrometry (MIMS), a variant of secondary ion mass... 

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