Imaging cell membrane synthesis

Fig. 27.5. Mesoporous silica nanoparticles as novel drug delivery systems, (a) Cocondensation method to form functionalized mesoporous silica structures in a surfactant template synthesis, (b) TEM image of mesoporous silica nanoparticles and sketch of a novel drug delivery particle which contains functionalized pores, closed by a gate, and is decorated with ligands for cell targeting, (c) Cell targeting by ligand-receptor interaction at the cell membrane, endosomal uptake and controlled release after pH change from early to late endosome...

FIGURE 10.28 Scanning electron microscopy (SEM) images of (a, b) Umbite and (c, d) ETS-10 supported on carbon Toray paper. (Erom Aused, M.P., Urbiztondo, M.A., MaUada, R., Pina, M.P., and Santamana, J., Synthesis of proton conducting membranes for direct metbanol fuel cells (DMPCs). Books of abstracts of tbe OSSEP Pinal Workshop, Tenerife, 2004, pp. 90-91.)... 

The hollow ATO-PANI spheres obtained via the Pickering approach were decorated by Pt nanoparticles using a standardized polyol process. The chosen synthesis protocol for Pt decoration used mild conditions, which hence did not impact the hollow sphere structure. The hollow spheres were then sprayed onto a commercial Nation membrane and applied at the cathode side of an MEA. Figure 7.14a depicts a cross-sectional SEM image of the oxidic hollow spheres. It can be clearly observed that the sphere structure is maintained after the polyol process for Pt decoration. Single cell tests of the novel electrode design showed a maximum power density of 58 mW cm and a platinum utilization... 

Cyclo-oxygenase 2 (COX-2) has been proposed as a target for noninvasive imaging of inflammation and cancer. This is based on the notion that COX is the critical enzyme in prostaglandin synthesis. COX-2, a membrane-bound enzyme, has potent inflammatory effects but is also overexpressed in colon, breast, lung, and other cancers. COX-2 overexpression results in decreased apoptosis and increased cell migration and proliferation. 

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