Image analysis standard reference materials

Due to the lack of suitable standard reference material for quantification purposes in phospho-proteomics and metallomics, reliable calibration strategies were developed for the direct microlocal analysis of phosphorus and metals in protein spots and in thin sections of brain tissue using LA-ICP-MS.16,17,116 For quantification of analytical data, the application of a solution based calibration strategy was proposed with LA-ICP-MS6 and the simultaneous determination of P, S, Si, Al, Cu and Zn concentrations in human brain proteins (Alzheimer s disease) or for imaging thin... 

A different researeh ehaUenge is the deteetion of novel explosives. Detectors are generally designed to look for speeifie explosives, both to limit the number of false or innoeuous positives and to allow a determination of whieh explosive has been detected. As a result, uovel explosives are unlikely to be detected until identifying characteristies and reference standards have been developed and incorporated into equipment designs. Unlike imaging techniques for deteeting bulk quantities of explosives, trace analysis provides no opportunity for a human operator to identify a suspieious material based on experience or intuition. 

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