IGFBP protein

IGFBP-3 insulin-like growth factor binding protein 3... 

Horney, M.J. et al. (2001) Synthesis and characterization of insulin-like growth factor (IGF)-l photoprobes selective for the IgG-binding proteins (IGFBPs) photoaffinity labeling of the IGF-binding domain on IGFBP-2./. Biol. Chem. 276(4), 2880-2889. 

The liver represents the major site of synthesis of the IGFs, from where they enter the blood stream, thereby acting in a classical endocrine fashion. A wide variety of body cells express IGF receptors, of which there are two types. Furthermore, IGFs are also synthesized in smaller quantities at numerous sites in the body and function in an autocrine or paracrine manner at these specific locations. IGF activity is also modulated by a family of IGF binding proteins (IGFBPs), of which there are at least six. 

D6. Damon, S. E., Maddison, L., Ware, J. L., and Plymate, S. R., Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formation. Endocrinology 139, 3456-3464 (1998). 

Salobir, B., Prezelj, J., Meden-Vrtovec, H., Kocijanic, A., and Osredkar, J., Insulin-like growth factor binding protein-3 (IGFBP-3) serum concentrations and ovarian responsiveness in in-vitro fertilization. Hum. Reprod. 11, 2208-2210 (1996). 

To establish the relationship between free IGF-1, binding proteins, and insulin sensitivity, 11 healthy volunteers were given IV glucose (0.3 g/kg) and insulin (0.05 U/kg) at two times, with each administration separated by 20 minutes (83). Blood samples were collected for measurement of free IGF-1, total IGF-1, IGFBP-1, and IGFBP-3. Free IGF-1 decreased by 20% 20 minutes after the first insulin administration and by 35% 20 minutes after the second administration. IFGBP-3 increased to 20% above the basal level. 

Baxter RC. Insulin-like growth factor (IGF) binding proteins The role of serum IGFBPs in regulating IGF availability. Acta Paediatr Scand Suppl 1991 372 107-14. 

Hwa V, Oh Y, Rosenfeld RG. The insuhn-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev 1999 20 761-87. 

---