Idiopathic primary onset

Primary insomnia includes a number of insomnia diagnoses according to the International Classification of Sleep Disorders, including psychophysiological insomnia and idiopathic insomnia [11]. Psychophysiological insomnia most closely resembles primary insomnia. Individuals with idiopathic or childhood-onset insomnia show a lifelong inability to obtain adequate sleep there is no evidence of medical or psychiatric disorders that could account for the sleep disturbance. In sleep disor-... 

Hereditary hemochromatosis is the most common hereditary form of hemochromatosis. It results from hereditary abnormalities of proteins that regulate iron hemosta.sis. In recent years, the genetic lesions responsible for many forms of the disease have been discovered. It is an adult onset disorder, formerly called primary hemochromatosis or idiopathic hemochromatosis, which is linked to the HLA loci on chromosome 6. 

Usually the cause of pulmonary hypertension can be assigned to related parenchymal lung disease, heart disease, thromboembolism, or pulmonary, vascular disease. Pulmonary hypertension is termed idiopathic (or primary), however, when it occurs in patients in the absence of associated cardiopulmonary disease and when no other apparent cause for the disease is discernible. Primary pulmonary hypertension is a very rare disease that occurs predominantly in young female patients between the ages of 20 to 40 years (Wood, 1956). It is usually progressive and fatal, with the average survival time from the onset of symptoms being 2 to 3 years (Bourdillon and Oakley, 1976). 

Two adults with pre-existing primary antibody deficiencies developed recurrent infections immediately after receiving rituximab for refractory idiopathic thrombocytopenic purpura [161 ]. The temporal relation between rituximab administration and the onset of infection suggested that rituximab accelerated immune deficiency in these patients. 

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