I.-2-Amino

Because they are similar, the aLkanolamines often can be used interchangeably. However, cost/perfomiance considerations generally dictate a best choice for specific appHcations. AMPD is manufactured in very low volumes for use as a reagent in certain medical diagnostic tests, although some is used in certain cosmetic products. 2-Ainino-1-butanol is used primarily as a taw material for the synthesis of ethambutol [74-55-5] an antituberculosis dmg. The first step in the synthesis of this dmg is the resolution of AB into its optical isomers because only (i)-2-amino-l-butanol, [5856-62-2] is utilized in this synthesis. 

For Schiff base being a derivative of gossypol and R-( I )-2-amino-3-benzyloxy-1-propanol, the conditions of the atropisomerisation were determined on the basis of the NMR spectra.37 The ratio of the diastereomers was established on the basis of the integrals of selected H signals (H-l and H-ll). The atropisomerisation of the gossypol Schiff base took place even if the samples were not exposed to the sunlight, however, this process was slower in the dark. The diastereopure Schiff bases were converted into a racemic mixture after ca. 12-14 h in the dark and ca. 3-3.5 h after irradiation of monochromatic light. The addition of a drop of water to acetonitrile solution accelerated the atropisomerisation. In this case, the 1 1 ratio of diastereomers was achieved after 45 min. The results obtained indicated that the atropisomerisation process cannot be considered as a simple photo-atropisomerisation. 

Isoleucine He I 2-Amino-3-methylpentanoic acidJ) CH3CH2 —C H(CH ) - CH (NHj) - COOH... 

The parent compound 309 was synthesized by the reactions of cis- or rra i-2-amino-l-cyclohexanecarboxamides with ethyl orthoformate [69-JCS(C)1635 71JCS(C)238]. In principle, 309 can exist in five tautomeric forms two enol forms, one lactim form, and the IH and 3H forms, of which the two enol forms can be excluded because no cis-trans isomerization was observed. The H and 3H forms may be fixed with substituents hence, 310 and 311 with fixed tautomeric structures were prepared. The UV spectra reveal that the unsubstituted derivatives exist in 3H form, as shown for structure 309 [71JCS(C)238]. 

I.4.I.2. Amino, Hydroxy, and Phenylthio Ketones Asymmetric hydrogenation of amino ketones, in either a neutral or hydrochloride form, has extensively been studied. Both Rh(I) and Ru(II) complexes with an appropriate chiral diphosphine give a high enantioselectivity. As described in Scheme 1.42, a-aminoacetophenone hydrochloride is hydrogenated using a cationic Rh complex with (R)-MOC-BIMOP, an unsymmetricaJ biaryl diphosphine, to give the... 

Indospicine (= I-2-Amino- Indigofera spicata, I. spp. (Fabaceae) cNOS, iNOS (Arginase)... 

Sudo and Saigo reported the application of c/i-2-amino-3,3-dimethyl-l-indanol derived l,3-oxazolidin-2-one 231 as a chiral auxiliary in asymmetric Diels-Alder reactions. The A-crotonyl and A-acryloyl derivatives were reacted with cyclopentadiene, 1,3-cyclohexadiene, isoprene and 2,3-dimethyl-l,3-butadiene, using diethylaluminum chloride as the Lewis acid catalyst. The reactions afforded the expected cycloadducts in moderate to high yields (33-97%) with high endo selectivities and high de values (92% to >98%). 

To a suspension of bis(salicylaldehydato)copper [32] (0.43 g, 1.4 mmol) in methanol (10 mb), a solution of i -2-amino-l,l-di-(2-methoxyphenyl)-3-phenylpro-panol (1.1 g, 3.0 mmol) in methanol (10 mb) was added in the course of 1 h. The addition was carried out with vigorous stirring at room temperature. After the... 

The amino alcohol, i -2-amino-l,l-di-(2-octyoxy-5-ferf-butyl-phenyl)-propa-nol, was prepared by the reaction of a Grignard reagent from 2-bromo-4-ferf-butylphenyl octyl ether [35] with D-alanine ethyl ester. The copper complex was prepared in the similar manner as above. In this case, neither the amino alcohol, the Schiff base, nor the copper complex was crystalline. 

D-2-amino-2-phenylacetainido)-3-chloro-3-cephem-4-carboxylic acid (6J ,7S)-7-[(i )-2-amino-2-phenylacetamido]-3-chloro-8-oxo-l-azabi(yclo[4.2.0]oct-2-ene-2-carboxylic acid... 

Paromomycin I 2-amino-2-deoxy-D-glucose (6) D-ribose paromamine (6)... 

NMDA receptors at which NMDA and quinolinic acid (QUIN) are selective agonists. NMDA receptors are competitively and very effectively blocked by a number of phosphono amino acids, notably (i -2-amino-5-... 

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