Hypsicity Oxidation Level Analysis

Classification of Juxtaposed Hammett EDGs and EWGs by Oxidation State  

FIGURE 5.2 Redox reactions as central link between various classes of organic reactions. 

This chapter begins by convincing the reader of the following benefits of the concept of oxidation number in organic chemistry through illustrative examples. 

Tracking oxidation numbers in a reaction mechanism intermediate by intermediate strengthens the link between reaction mechanism and balanced chemical equations that account for all products in a chemical transformation 

Spotting which atoms are oxidized or reduced in a transformation, especially deep-seated redox transformations 

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Scheme 4.10 Craig synthesis of nicotine showing key atoms for hypsicity (oxidation level) analysis.

As an example, Scheme 4.10 and Table 4.8 summarize the hypsicity analysis for the Craig plan. Hypsicity indices for all plans are given in column 8 of Table 4.7. Figure 4.34 illustrates the change in oxidation level profiles as a function of reaction stage. It turns out that the Campos plan with the highest RME is also the one with an HI closest to the isohypsic condition of HI = 0. In Table 4.8 a check on the computation of 2 made by taking... 

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