Hypoxylon oceanicum

Marine microorganisms have also been reported to produce bioactive peptides, such as marinostatin from the marine bacterium Alteromonas sp. [319], pentapeptides from the cyanobacterium Ambaena cylindrica [320], and new anti-inflammatory cyclic peptides from the marine Streplomyces sp. [321], From the marine fungus Hypoxylon oceanicum, several lipodepsipeptides with antifungal activity have recently been reported [322,323],... 

Cultures of the marine fungus Hypoxylon oceanicum (LL-15G256) were found to have potent anti-fungal activity in assays designed to detect... 

Three new correlated peptidic alkaloids (lipodepsipeptides), LL-15G2568 (136), -e (137) and -y(138), were isolated from the fermentation broth and cells of the LL-15G256 strain of Hypoxylon oceanicum Schatz, (Xylariaceae) [87,139]. All of them contain D-glutamate, L-serine and the rare amino acid P-ketotryptophan. Their absolute configuration was obtained on the basis of spectral studies and GC/MS analysis of serine and glutamic acid derivatives. 

In their studies of the optimal fermentation conditions of Hypoxylon oceanicum (Ascomycotina, Xylariaceae), Abbanat et al. [188] also established that a high NaCl concentration (from 0% to 90% sea water in the medium) is not favorable for accumulation of L-15G256Y (133), a lipodepsipeptide. They observed that a relatively high temperature (from 22 to 28°C) is a favorable factor for its production. 

Schlingmann, G., Milne, L., Williams, D.R., and Carter, G.T. (1998) Cell wall-active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. Isolation and structure determination./. Antibiot., 51, 303-316. 

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