Hypoxia responsive element

Oosthuyse, B., Moons, L., Storkebaum, E. et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promotor causes motor neuron degeneration. Nat. Genet. 28 131-138, 2001. 

Semenza, G.L., B. Jiang, S.W. Leung, R. Passantino, J. Concordet, P. Maire, and A. Giallongo (1996). Hypoxia response elements in the aldolase A, eno-lase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia Inducible Factor-1. J. Biol. Chem. 271 32529-32537. 

Olenyuk BZ, et al. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc. Natl. Acad. Sci. U.S.A. 2004 101 16768-16773. 

Delivery of gene transfer systems of heat shock proteins (Hsp70),250 antioxidant enzymes (catalase)251 or survival genes (Akt)252 has been associated with myocardial protection against ischemia and reperfusion. A vector gene therapy system has also been developed with a hypoxia response element-incorporated promoter to turn on the gene expression in response to hypoxic signal.253... 

List of Abbreviations HIF, hypoxia-inducible factor HREs, hypoxia response elements Hsps, heat-shock proteins iNOS, inducible nitric oxide synthase NE, noradrenabne ODG, oxygen-dependent genes ROS, reactive oxygen species TH, tyrosine hydroxylase... 

HIF-1a moves to nucleus forms dimer with ARNT thereafter binding to hypoxia response elements (HRE) in the control region of hypoxia-inducible gene... 

Rees BB, Bowman JA, Schulte PM. 2001. Structure and sequence conservation of a putative hypoxia response element in the lactate dehydrogenase-B gene of Fundulus. Biol Bull 200 247-251. 

Minchenko, A. J. Caro. Regulation of endothelin-1 gene expression in human microvascular en-dorhelial cells by hypoxia and cobalt Role of hypoxia responsive element. Mol. Cell Biochem. 2000, 208, 53-62. 

Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, Hankinson O (2007) A novel promoter element eontaining multiple overlapping xenobiotie and hypoxia response elements mediates induetion of cytoehrome P4502S1 by both dioxin and hypoxia. J Biol Chem 282 10881-10893... 

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