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Hypoxia-ischemia excitotoxic injury

The forces driving water flow to form cytotoxic edema are osmotic, generated in brain injury conditions (ischemia, trauma, hypoxia) by disturbances in ionic homeostasis due to failure of the Na /K+ ATPase and/or dramatic influx of Na" and Ca " via ionotropic glutamate receptors (excitotoxicity) and other ionic channels. These pathological alterations in cellular ionic homeostasis result in Na" " and water flow from the intravascular and extracellular space into the intracellular compartment. [Pg.133]

Excitotoxicity also plays a role in epileptic seizures and cerebral ischemia. During ischemic injury, a rapid accumulation of glutamate takes place. This induces a noxious Ca + influx into the cytoplasm. The Ca + conductance of NMDA receptors explains the efficacy of NMDA antagonists against hypoxic damage. In addition, AMPA antagonists have also a protective function in hypoxia (Siesjo et al., 1991)... [Pg.473]

See other pages where Hypoxia-ischemia excitotoxic injury is mentioned: [Pg.559]    [Pg.563]    [Pg.565]    [Pg.571]    [Pg.757]    [Pg.4718]    [Pg.455]    [Pg.455]   
See also in sourсe #XX -- [ Pg.563 , Pg.564 ]



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