Hypothyroidism adolescents

An abstract reported that 23% of 61 children and adolescents taking lithium and divalproex sodium for up to 20 weeks had a TSH concentration over 10 mU/1 (reference range 0.2-6.0) however, no clinical information was provided (635). Another abstract reported that the prevalence of thyroperoxidase antibodies was higher in bipolar outpatients (28% of 226) than in psychiatric inpatients with any diagnosis (10% of 2782) or healthy controls (14% of 225), but this was not related to lithium exposure on the other hand, hypothyroidism was associated with lithium exposure, especially in the presence of antithyroid antibodies (636). 

Body II, Chanoine IP, Dumon JC, Delange F. Circulating calcitonin levels in healthy children and subjects with congenital hypothyroidism from birth to adolescence. J Endocrinol Metab 1993 77 565-7. 

Antithyroid drugs Noninvasive Lower initial cost Low risk of permanent hypothyroidism Possible remissions due to immune effects Low cure rate (30%-80% average 40%-50%) Adverse drug reactions Drug compliance Lirst-line treatment in children, adolescents, and in pregnancy Initial treatment in severe cases or preoperative preparation... 

The prevalence of hypothyroidism appears to be lower in adolescents and in African Americans compared to the rest of the population. 

Harel Z, Biro FM, Tedford WL. Effect of long term treatment with sertraline (Zoloft) simulating hypothyroidism in an adolescent. J Adolesc Health 1995 16 232-234. 

I therapy as absolutely safe at each age (31 ). Indeed the actual total follow-up period in children and adolescents is still much lower than the average time interval (25 years) between X-ray irradiation of the neck and thyroid cancer. Although the occurrence of hypothyroidism after I therapy is usually considered as an unwanted side effect, intentional thyroid destruction has in some cases, when follow-up is likely to be difficult, been successfully( ) attained... 

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