Hypothesis Construction and Testing

Unlike superiority trials, for which p-values are employed to determine if a new drug s efficacy is statistically significantly superior to that of the comparator drug, p-values are not typically used in noninferiority trials. Establishing noninferiority is based on the use of confidence intervals. 

As for a superiority trial design, there will be a research question, a research hypothesis, and a null hypothesis. However, these will be phrased quite differently from those for a superiority trial. They are as follows  

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