Hypotensive peptides

FitzGerald R J, Murray B A and Walsh D J (2004), Hypotensive peptides from milk proteins, Journal of Nutrition, 134, 980S-988S. 

Shiozaki, K., Shiozaki, M., Masuda, J., Yamauchi, A., Ohwada, S., Nakano, T., Yamaguchi, T., Saito, T., Muranoto, K., and Sato, M. (2010). Identification of oyster-derived hypotensive peptide acting as angiotensin-I-converting enzyme inhibitor. Fish Sci. 76, 865-872. 

Carraway R, Leeman SE. Isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J. Biol. Chem. 1973 248 6854-6861. 

Inhibition of NEP also prevents the degradation of atrial natriuretic factor (ANF), a natural hypotensive peptide. Dual inhibitors of NEP and ACE have been designed successfully because both enzymes share significant structural homology, particularly in their active sites. Simultaneous inhibition of both peptidases produces a more powerful hypoten-... 

Another Beecham compound, BRL 13776 (25) has shown antihypertensive properties due to noradrenaline depletion in DOCA rats and renal hypertensive cats.98 Only the medulla/pons region of brain showed significant drops in noradrenaline, in contrast to reserpine. There were no behavioural effects and the compound is being taken to clinical trial. A novel hypotensive peptide, hypotensin, has been isolated from the venom of the Western diamondback rattlesnake.99 It contains approximately 20 amino-acid residues and appears unrelated to the kinins. The hypotensive effect is said to be dose-related after oral administration in normal rats and SHRs and is not consequent upon histamine release. Brief details of a clinical trial of a PGEp analogue (26) are available.100 Eleven of seventeen hypertensives responded with lower blood pressure to oral doses (10-20 pig) of 26. A recent studylOl of the marked antihypertensive properties of the diuretic Indapamide (27)(SE 1520, Servier) in rats and cats shows it to reduce vascular reactivity on chronic dosing. 

Hypotensive Peptides. Proceedings of the International Symposium, Florence, Italy, Oct. I965. Ed. hy E. G. 

FitzGerald, R.J., Murray, B.A., Walsh, D.J., 2004. Hypotensive peptides from milk proteins. The Journal of Nutrition 134, 980S—988S. 

BIOCHEMICAL ASPECTS OF HYPOTENSIVE PEPTIDE ACTION N. Back, and H. Wilkens... 

Kinins have been classified as hypotensive peptides resembling bradykinin in both structure and pharmacologic activity (1). 

Erdos, E. G., Back, N., and Sicuteri, F. Eds. Hypotensive Peptides (Proc. Florence Symposium, 1965) Springer-Verlag, New York, 1966. 

At present, the term kinin is a generic name for polypeptides characterized by the following biological effects lowering of blood pressure, contraction of most smooth-muscle preparations, increase of capillary permeability, pain production and bronchoconstiiction in the guinea-pig. The reader is reminded that the nomenclature of this group of substances and of the enzymes which liberate them, as well as the enzymes which inactivate them, is not uniforuL In this chapter, the recommendations of the Committee on Nomenclature for Hypotensive Peptides have been followed... 

In addition to these substances, which can be clearly classified as kinins, other hypotensive peptides have been isolated from mammalian and non-mammalian tissues. The spectra of their biological activities, apart from the lowering of blood pressure, differ in part from those of kinins. Substance P, a polypeptide isolated from the brain and intestine, possessing a possible rdle in the nervous system, is certainly of considerable interest Among non-mammalian hypotensive... 

Hypotensive Peptides," Ed. by E. G. Erdos, N. Back, p. Sicuteri and A. F. Wilde, Sprlnger-Verlag, New York, 1966. 

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