Hypoglycemic drugs drug interactions

Significant drug-drug interactions are those that potentiate the effects of other agents and require dosage modification. These include certain anticoagulants, hypoglycemic sulfonylureas, and hydantoin anticonvulsants. 

The most potentially serious drug interactions include the concomitant use of NSAIDs with lithium, warfarin, oral hypoglycemics, high-dose methotrexate, antihypertensives, angiotensin-converting enzyme inhibitors, fi-blockers, and diuretics. 

Drug interactions Sandostatin has been associated with changes in nutrient absorption, so it may effect the absorption of orally administered drugs. Concomitant administration of Sandostatin with cyclosporine may decrease blood levels of cyclosporine and result in transplant rejection. Patients receiving insulin, oral hypoglycemic agents, beta blockers. 

Drug Interactions May enhance anticoagulant effects of coumarin-like drugs Rifampin INH Cyclosporine Phenytoin Hypoglycemic agents Terfenadine Astemizole... 

Hypoglycemia can also result from drug interactions, with the simultaneous use of drugs that have glucoselowering effects or that inhibit the clearance of oral hypoglycemic drugs. 

Table 2 Drug interactions with oral hypoglycemic drugs...

Chloramphenicol Palmitate Chloramphenicol has concentration-dependent incompatibility with many drugs. Chloramphenicol has severe toxic effects, and overdose may be treated by hemoperfusion of charcoal. It interacts with coumarin anticoagulants, some oral hypoglycemics, antiepileptic drugs, and nutrients such as iron and vitamin B12. 

Acarbose Acarbose interacts with other hypoglycemics and drugs that act on the GI tract. Neomycin and cholestyramine interact with acarbose. 

Associated with renal dysfunction (4 PGs) and hypoglycemia. Many drug interactions (ethanol T GI bleeding, T effects of sulfonylurea hypoglycemics, and warfarin, 4 effects of uricosurics). 

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