Hyperuricemia definition

Hyperuricemia may be an asymptomatic condition with an increased serum uric acid level as the only apparent abnormality. Statistically, hyperuricemia is defined as serum urate concentrations greater than two standard deviations above the population mean. However, for determination of the risk for gout, hyperuricemia is defined as a supersaturated urate concentration. By this definition, a urate concentration greater than 7.0 mg/dL is abnormal and is associated with an increased risk for gout. This corresponds to a measured value greater than 7.5 mg/dL by most autoanalyzers. 

Critical for the definition of hyperuricemia is always the solubility of uric acid or its salts in serum this is a biochemical value, which is commonly calculated as 6.4 mg% (380 jumol/liter) and is the same for both males and females. Uric acid values exceeding this pathological limit of 6,4 mg% in serum are therefore critical, as uric acid is then able to crystallize, especially in the bradytropnic tissue. Furthermore this mechanism is supported by a move of the pH value to the acid range induced by the uric acid itself. 

Robinul 2 mg was administered orally to a total of 34 subjects. Thirteen subjects had gout and had received no hypouricemic therapy for 2 weeks prior to the study. Six subjects had borderline or definite asymptomatic hyperuricemia with serum urate values ranging from 6.7 to 7.1 mg%. The remaining 15 subjects were normouricemic with serum urate values ranging from 3.3 to 6.2 mg%. Care was taken... 

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