Hyperthyroidism myopathy

Human creatine kinase -MM MAK33 IgGl Cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle s disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, A. thaliana A. thaliana 2S2 seed storage protein SP + 0.02-0.4% TSP of fresh leaf extract (10-12% TSP of intercellular fluid) 52... 

An interesting hypermetabolic myopathy was discovered and biochemically explored by Luft et al. (L7). There was no evidence of hyperthyroidism, and mitochondria from biopsied muscle had a high rate of respiration and a loosely coupled state of oxidative phosphorylation. A few other cases of unusual myopathies with loosely coupled mitochondria have since been described (e.g., S12), although it does not seem that this is a single disease entity. 

Amiodarone CNS, corneal microdeposits/blurred vision, optic neuropathy/neuritis, Gl, aggravation of underlying ventricular arrhythmias, torsade de pointes, bradycardia or AV block, bruising without thrombocytopenia, pulmonary fibrosis, hepatitis, hypothyroidism, hyperthyroidism, photosensitivity, blue-gray skin discoloration, myopathy, hypotension and phlebitis (IV use)... 

In hyperthyroidism, the commonest neuromuscular dysfunction is proximal myopathy. 

The adrenergic symptoms of hyperthyroidism, such as palpitation, tremor, anxiety, or heat intolerance are promptly relieved by coadministration of betablockers. Nonselective betablockers, such as propanolol, are preferred because of their more direct effect on hypermetabolism with positive effect of tremor or myopathy and the peripheral inhibition of conversion from T4 to T3 (Nolte 1995). The dose should be increased progressively until symptoms are controlled. Betablockers should be used cautiously in patients with intrinsic asthma or congestive heart failure. 

Creatine is present in muscle, brain, and blood and, although not present in large amounts in normal urine from adults, it is abundantly present in the urine of adults who have recently ingested creatine supplements. Ingestion of a creatine supplement has been shown to increase the level of phosphocreatine, and this has become extremely popular in recent years with many athletes who want to increase muscular power and to enhance their performance. Because of this, analysis for creatine has become more important in the clinical setting. Additionally, elevated serum concentrations of creatine can be observed in some cases of muscle catabolism such as primary myopathy, myositis, and muskelatrophie, as well as in the case of hyperthyroidism. 

A test for the investigation of myopathies in which creatine is given orally and its output in the urine is measured. Increased urine creatine excretion (i.e. reduced tolerance) is found when the muscle mass is reduced or the muscle is unable to take up creatine (e.g. hyperthyroidism and muscular dystrophy). Decreased urinary creatine excretion (i.e. increased tolerance) is. found in hypothyroidism. 

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