Loose coupling

We prove our statement in two steps First, we consider the special case of a Hilbert space of three states, the two lowest of which are coupled strongly to each other but the third state is only weakly coupled to them. Then, we extend it to the case of a Hilbert space of N states where M states are strongly coupled to each other, and L = N — M) states, are only loosely coupled to these M original states (but can be stiongly coupled among themselves). 

P3-Dk original Duke PME code, loosely coupled to SigmaX, low accuracy... 

Increasing vibration with speed. Loose rotor components Loose coupling hub... 

Check each coupling for makeup. If the stand off is abnormally great, check the coupling for tightness. Loose couplings should be removed. 

Scientific progress is based ultimately on unification rather than fragmentation of knowledge. The important sub-disciplines of a scientific discipline have been altogether too loosely coupled to the frontier in the first place, and this has compromised their ability to take the next step forward. The time is upon us to recognize that the new frontier is the interface, wherever it remains unexplored (Kafatos and Eisner 2004). 

Collier ML, Ji G, Wang Y, Kotlikoff MI 2000 Calcium-induced calcium release in smooth muscle loose coupling between the action potential and calcium release. J Gen Physiol 115 653-662... 

FIG. 4. Model of RyR-mediated Ca2+ release in muscle. Evidence indicates allosteric coupling between the L-type Ca2+ channel and RyRl in skeletal muscle, tight coupling between the channels in cardiac (RyR2), and loose coupling to localized RyR (probably RyR2) in smooth muscle. 

Holton Loose coupling would be another explanation. You are working on rabbit bladder. Imaizumi s group have worked on guinea-pig, and in the vas deferens and urinary bladder they see a spark or hotspot within 10 ms of a depolarization. You can either retreat into a species difference argument, or perhaps they selected their cells very heavily. 

Nelson We have looked at guinea-pig bladder and we have the same results as Mike Kotlikoff in terms of the loose coupling. 

Frj That s an ideal mechanism. Essentially what you have is loose coupling, but the other way around, with the PLC mechanism. But you also have a rapid mechanism, which is autocatalytic on the receptor itself. You have a mechanism for producing something, but also a phase lag system that would generate a wave. 

Fry You need both to produce the wave, but you have a mechanism there for producing a wave. If only you could show that in the smooth muscle cell you had this loose coupling. 

Transient BK currents in UBSM evidence in support of loose coupling of VDCCs andRjR.r... 

BK currents consisted of transient and steady-state components. The transient currents were abolished by ryanodine (10 fiM), indicating that they are activated by Ca2+ sparks. The lag from the onset of depolarization (activation of VDCCs) to the first transient BK current was around 50 ms. This delay is much too long to be attributed to local signalling from VDCCs to RyRs such as occurs in heart, and instead is consistent with the idea of loose coupling between VDCCs and RyRs (Fig. 1 A) (Collier et al 2000). Spark-activated transient BK currents remained in the presence of the VDCC antagonist diltiazem (50 //M). However, the frequency of... 

TCM is loosely coupled with DCM (Dictionary of Chinese Medicine) and PARK (Photo ARKive) and establishes relationships with Planet and WDI. 

Aldosterone and other steroids with mineralocorticoid properties promote the reabsorption of sodium from the distal part of the distal convoluted tubule and from the cortical collecting renal tubules, loosely coupled to the excretion of potassium and hydrogen ion. Sodium reabsorption in the sweat and salivary glands, gastrointestinal mucosa, and across cell membranes in general is also increased. Excessive levels of aldosterone produced by tumors or overdosage with synthetic mineralocorticoids lead to hypokalemia, metabolic alkalosis, increased plasma volume, and hypertension. 

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