Hypertension dipyridamole

Apart from surgical and interventional therapy of occlusive carotid artery disease, the major approach to preventing vascular disease and subsequent stroke is to pay close attention to the control of modifiable risk factors such as hypertension, smoking, diabetes, and hypercholesterolemia. Coumadin, an anticoagulant, is effective for the primary and secondary prevention of stroke in patients with atrial fibrillation. Aspirin, clopidogrel, and the combination of aspirin and dipyridamole have been proven to be effective for secondary stroke prevention along with the antihypertensive combination of indap-amide and perindopril. 

A patient with aorto-iliac occlusive vascular disease and hypertension suffered a stroke 6.5 minutes after administration of intravenous dipyridamole during a thallium myocardial study (11). Aminophylline did not reverse its progression. 

A 67-year-old woman with hypertension, who was taking metoprolol 50 mg bd, underwent dipyridamole stress testing, and during the infusion of dipyridamole developed nausea, dizziness, and sudden loss of consciousness. 

Nervous system The susceptibility factors for dip)Tidamole-induced headache have been studied in an analysis of data from the European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT) and the Second European Stroke Ifrevention Study (ESPS 2). In ESPRIT, dipyridamole-induced headache was significantly associated with female sex, absence of hypertension, and nonsmoking, and in ESPS 2 with female sex and absence of ischemic lesions on imaging [143 ]. 

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