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Hypersegmentation

Most hematological adverse effects associated with trimethoprim have been reported with co-trimoxazole. These include macrocytic and megaloblastic anemia, aplastic anemia, neutropenia, hypersegmentation of leukocytes, thrombocytopenia, and pancytopenia (12,61-63,75-79). Sulfonamides alone have not been associated with folate deficiency, but in combination with trimethoprim they can deplete folate stores in patients with preexisting deficiency of folate or vitamin B12 (80). Treatment with co-trimoxazole can impair the function of mobilized autologous peripheral blood stem cells (81). [Pg.3512]

Low serum folate Hypersegmentation of neutrophils High urine FIGLU with a histidine dose Low red blood cell folate Appearance of megaloblasts in marrow Megaloblastic anemia... [Pg.508]

Unmasking covert folate deficiency in iron-deficient subjects with neutrophil hypersegmentation dU suppression tests on l3nnphocytes and bone marrow, B. J. Haematol.,... [Pg.85]

See other pages where Hypersegmentation is mentioned: [Pg.677]    [Pg.81]    [Pg.119]    [Pg.128]    [Pg.182]    [Pg.507]    [Pg.513]    [Pg.990]    [Pg.507]    [Pg.513]    [Pg.1103]    [Pg.922]    [Pg.277]    [Pg.21]    [Pg.262]    [Pg.677]    [Pg.81]    [Pg.119]    [Pg.128]    [Pg.182]    [Pg.507]    [Pg.513]    [Pg.990]    [Pg.507]    [Pg.513]    [Pg.1103]    [Pg.922]    [Pg.277]    [Pg.21]    [Pg.262]   
See also in sourсe #XX -- [ Pg.18 ]



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Hypersegmentation, of neutrophils

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