Hyperparathyroidism clinical presentation

Clinical Presentation of Secondary Hyperparathyroidism and Renal Osteodystrophy ... 

Warner et al, 2004). Moreover this study points out that there can be overlap in the clinical presentations of FHH and primary hyperparathyroidism, particularly in familial forms of the latter. 

Mundy GR, Cove DH, Fisken R. Primary hyperparathyroidism Changes in the pattern of clinical presentation. Lancet 1980 1 1317-20. 

The present article reviews current knowledge of the properties and physiological eflEects of parathyroid hormone and compares the latter with the biochemical disturbances of clinical hyperparathyroidism. In the course of this review, the concentrations of calcium and phosphate in extracellular fluid are considered and related to the solubilities of the calcium phosphate salts and to the solubility of bone mineral itself. 

Hyperparathyroidism disturbs calcium metabolism, and leads to hypercalcemia, bone atrophy, and nephrolithiasis. These three symptoms are usually present together, yet one of them may dominate the clinical picture. In recent decades, the incidence of renal disease seems to have increased, and that of bone disease decreased among patients with reported hyperparathyroidism. 

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