Hyperlipidemia case study

The incidence of acute pancreatitis as a suspected complication of finasteride treatment has been examined in a case-control study in a Danish regional population of 490 000 over 7 years. Of 302 men aged 60 and older with incident acute pancreatitis, three had been exposed to finasteride of 2994 controls 37 had been exposed to finasteride. After adjustment for alcohol-related diseases, gallstone disease, hyperlipidemia, hypercalcemia, and hyperparathyroidism, the authors found no evidence of an increased risk of acute pancreatitis in users of finasteride (48). 

Familial Combined Hyperlipidemia About 10% to 15% of patients with premature CHD actually have familial combined hyperlipidemia (FCHL). This disorder is recognized as a distinct phenotype by studying family members of survivors of myocardial infarction. Patients with FCHL can have increased plasma concentrations of total and LDL cholesterol (type Ila), or triglyceride (type IV), or both (type lib). In all cases, apo B-lOO concentrations are increased. The presentation of lipoprotein patterns can vary in an individual with time. Furthermore, patients with hypertriglyceridemia with normal partners tend to have offspring with hypercholesterolemia, and vice versa. 

In the only large study ever done to assess risk factors for stroke in young people (age 20-49) over a 1 -yr period (in Poland, a country where ephedra based products are widely used), nearly half the stroke cases were associated with preexisting hypertension, another 15% had hyperlipidemia, and 6% were diabetic (Jovanovic, 1996). None of the individuals were ephedrine users. 

Observational studies In a single-center study in 86 liver transplant recipients taking sirolimus, eight had too short a follow-up to include them in the analysis of long-term results, 38 were treated with sirolimus as the main immunosuppressant, and the other 40 took sirolimus-I-caldneurin inhibitors [124. Of the 86 patients, 82 developed a total of 92 adverse reactions hyperlipidemia ( =44), leg edema ( =20), anemia ( = 12), oral ulcers (n=5), rashes (n=5), diarrhea and leukopenia (two each), and thrombocytopenia and cardiomyopathy (one each). Sirolimus was withdrawn because of severe adverse reactions in seven cases, including generalized rashes (n=3), and cardiomyopathy, leg edema, diarrhea, anemia, and oral ulcers (one each). Rashes and cardiomyopathy developed soon after sirolimus introduction, the other adverse reactions usually had a gradual onset of several months. The leg edema in 20 patients resolved spontaneously in 7,... 

First of all, the typing of hyperlipemias seems to be essential requirement inasmuch as the responses of the Types to diet or drugs are substantially different. Several of the lipoprotein abnormahties appear to lead to vascular disease at an accelerated rate. In Lebanon, for example, there are relatively more cases of hyperlipidemia of Type II. These patients are predominantly children, who have xanthomas in their pre-teen years, angina and typical coronary artery disease in their teens, and an outlook for an average life-expectancy of 25 years [447]. Hyperlipidemia appears to be the primary disease in these children and apparently, leads to the secondary and fatal coronary artery disease. A thorough study of the abnormal lipoproteins of these children is obviously a necessity. 

Vitamins Bg, B12 and folate have specific and vital functions in the metabolism a deficiency (or excess) causes specific diseases such as hyperlipidemia, hypertension, obesity or cardiovascular diseases, which are related to a modern lifestyle and common in industrialized countries. As observed in several studies, cobalamin (B12) deficiency in most cases coincides with an insufficient folate status (Ball 2006 Howard et al. 1998 Morris et al. 2007). 

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